Calorimetric Research of Calcium Loaded PLGA Drug Delivery Nanoparticles

Author: Nata Goletiani
Keywords: Nanoparticles, PLGA, Calcium, Calcium Salts
Annotation:

The aim of this thesis is to determine how good of carriers PLGA nanoparticles are for calcium salts, as the frequency of use of calcium-containing drugs has changed and increased in recent years. Placing calcium in nanoparticles and bringing it to the target point with less losses is a very important step for scientists, because it allows to increase the amount of calcium in the target point on the one hand, and on the other hand, calcium placed in nanoparticles will not cause side effects. The master thesis is dedicated to the calorimetric study of Poly(Lactic-co-glycolic Acid) (PLGA) drug carrier nanoparticles containing calcium drugs (calcium carbonate, calcium gluconate, calcium fluoride, calcium phosphate and calcium sulfate). In addition to the general literature review, the experiments carried out by us, which were carried out on a calorimeter, are also evaluated, through which it is possible to determine the thermostability of nanoparticles containing calcium salts and its structural stability with respect to environmental conditions. In the thesis, we measured and compared pure PLGA nanoparticles with PLGA nanoparticles containing calcium salts. As a result, the amount of their heat of melting is calculated, which depends on the content of calcium ions in PLGA nanoparticles. In particular, the heat absorption peaks of complex PLGA nanoparticles decrease with an increase in the concentration of calcium-containing salts. The conducted experiments and obtained results allow us to use PLGA nanoparticles as a transporter of calcium-containing drugs and as an effective therapeutic agent in living organisms.