Studying chiral recognition mechanisms with a combination of experimental and theoretical methods

Author: Ketevan Museridze
Keywords: Chiral recognition, electrophoresis, NMR
Annotation:

The goal of this research is to study the chiral recognition mechanisms of using on chiral substances and chiral selectors, specifically cyclodextrins. As chiral recognition is based on intermolecular interactions, therefore the research requires multi-faceted approaches and different research methods. One of the methods is capillary electrophoresis, which allows us to study the affinity of each enantiomer to cyclodextin. In addition, the research aims to determine the structure of the complex, which is possible with nuclear magnetic resonance spectroscopy, in particular, ROESY (Rotating-frame nuclear Overhauser Effect Spectroscopy). Thus, the methods allow us to obtain complementary information about the selector-selectand. On the one hand, through capillary electrophoresis, we establish that there is an enantioselective interaction (chiral recognition), and through nuclear magnetic spectroscopy, we determine what causes this recognition.