"The role of Cyb5r3-cofactor of the liver P-450 system in the pathogenesis of epilepsy- creation of an experimental model"

Author: sergo gegechkori
Keywords: Epilepsy, cofactor protein, cholinergic system, low-calorie diet
Annotation:

Epilepsy is a chronic neurological condition characterized by an imbalance between the excitatory and inhibitory systems in the brain. Some forms of epilepsy are resistant to traditional antiepileptic drugs, making it crucial to understand the underlying pathophysiological mechanisms for the development of new treatment strategies. The cholinergic system has been suggested to play a significant role in the interaction between excitatory and inhibitory neurotransmitter systems in the brain. Research indicates that acetylcholine, which is formed by combining choline and acetyl-CoA, may influence excitatory processes in the brain during the early postnatal period. Acetyl-CoA, a product of aerobic glycolysis, is necessary for the proper functioning of enzymes involved in glycolysis. The liver's P450 system, specifically the protein-cyb5r3, distinguishes between exogenous and endogenous substrates, allowing enzymes to connect with suitable substrates. In our ongoing scientific research project, we have developed an experimental model to activate the protein-cyb5r3 and will investigate its effects on the neurotransmitter system.

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