Investigation of the enantiomer affinity pattern of mianserin, nomifensine and primaquine towards various cyclodextrins using capillary electrophoresis.

Author: Nino Jajanidze
Keywords: Enantiomers, capillary electrophoresis
Annotation:

The aim of this research was to study the affinity pattern of enantiomers of an antidepressant drugs Mianserin and Nomifensineand also Primaquine (which is used to treat and prevent malaria) with various, native and substituted CDs. a-, b- and γ-CDs were used as native CDs. These CDs consist of 6, 7, and 8 glucopyranose rings respectively. Therefore, their cavity sizes are different. In all three cases, the enantiomers were baseline separated using b- and γ-CDs, however, no separation wasobserved for a-CD. To study the migration order, the enantiomers were fractionated using high-performance liquid chromatography (HPLC). Then CE analysis was performed using the sample enriched with an enantiomer.

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Annotation [en]
ანოტაცია [ka]